When a monkey named Jojo found his mojo, it was bad news for the Powerpuff Girls. Blossom, Bubbles and Buttercup have dedicated their lives to fighting crime and the forces of evil. Jojo had dedicated his life to crushing the Powerpuff Girls. But Oh... No... Could it be Jojo's major mistake is the reason Blossom, Bubbles and Buttercup have super powers in the first place?